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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASP9 All Species: 4.24
Human Site: S99 Identified Species: 7.78
UniProt: P55211 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55211 NP_001220.2 416 46281 S99 N R Q A A K L S K P T L E N L
Chimpanzee Pan troglodytes Q5IS54 277 31588
Rhesus Macaque Macaca mulatta XP_001082859 416 46192 S99 N R Q A V K L S K P T L E N L
Dog Lupus familis XP_865164 414 45235 K99 S R Q A D P S K L T P G K L A
Cat Felis silvestris
Mouse Mus musculus P29594 452 50642 V128 T L S D I Q H V L P P L S C D
Rat Rattus norvegicus P55215 452 50709 I128 T L S D I Q H I L P P L S C D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520982 366 40213 F76 G D V C V K P F V P V P S T T
Chicken Gallus gallus Q98943 424 47941 G103 T E S S L R H G I A T L E Q R
Frog Xenopus laevis P55866 282 32106
Zebra Danio Brachydanio rerio NP_001007405 436 48445 P97 G D G V H R P P V I S V Q P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02002 323 35908 P39 T D A K G C T P E S L V V G G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42573 503 56598 N98 L A R S V D S N A V E F E C P
Sea Urchin Strong. purpuratus XP_799258 437 48470 G97 S A S G P S Q G Q M G Q T Q A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22.8 93.9 76.9 N.A. 28.9 28.3 N.A. 52.8 31.1 22.6 47.2 N.A. 22.1 N.A. 21.6 32.2
Protein Similarity: 100 35.8 96.8 84.1 N.A. 46.9 46.2 N.A. 65.6 48.3 38.7 64.2 N.A. 35.8 N.A. 37.5 51
P-Site Identity: 100 0 93.3 20 N.A. 13.3 13.3 N.A. 13.3 20 0 0 N.A. 0 N.A. 6.6 0
P-Site Similarity: 100 0 93.3 33.3 N.A. 20 20 N.A. 13.3 33.3 0 26.6 N.A. 13.3 N.A. 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 8 24 8 0 0 0 8 8 0 0 0 0 16 % A
% Cys: 0 0 0 8 0 8 0 0 0 0 0 0 0 24 0 % C
% Asp: 0 24 0 16 8 8 0 0 0 0 0 0 0 0 16 % D
% Glu: 0 8 0 0 0 0 0 0 8 0 8 0 31 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % F
% Gly: 16 0 8 8 8 0 0 16 0 0 8 8 0 8 8 % G
% His: 0 0 0 0 8 0 24 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 16 0 0 8 8 8 0 0 0 0 0 % I
% Lys: 0 0 0 8 0 24 0 8 16 0 0 0 8 0 0 % K
% Leu: 8 16 0 0 8 0 16 0 24 0 8 39 0 8 16 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 16 0 0 0 0 0 0 8 0 0 0 0 0 16 0 % N
% Pro: 0 0 0 0 8 8 16 16 0 39 24 8 0 8 8 % P
% Gln: 0 0 24 0 0 16 8 0 8 0 0 8 8 16 0 % Q
% Arg: 0 24 8 0 0 16 0 0 0 0 0 0 0 0 8 % R
% Ser: 16 0 31 16 0 8 16 16 0 8 8 0 24 0 8 % S
% Thr: 31 0 0 0 0 0 8 0 0 8 24 0 8 8 8 % T
% Val: 0 0 8 8 24 0 0 8 16 8 8 16 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _